This book describes Portal Vein Thrombosis, Diagnosis and Treatment and Related DiseasesPortal vein thrombosis (PVT) is the blockage of the portal vein by a thrombus (blood clot).The portal vein, also called the hepatic portal vein, is a vital vessel... Read more

This book describes Portal Vein Thrombosis, Diagnosis and Treatment and Related DiseasesPortal vein thrombosis (PVT) is the blockage of the portal vein by a thrombus (blood clot).The portal vein, also called the hepatic portal vein, is a vital vessel that supplies up to 75% of blood supply to the liver.This vein permits the blood to flow from the intestines to the liver.A PVT stops this blood flow.While PVT is treatable, it can be life-threatening.Acute and chronic PVT is regarded distinct medical disorders even though they indicate the progression of the same disease state.1. Acute PVT suggests a sudden total or partial blockage of the portal vein, and patients may present with no symptoms, or with abdominal pain, nausea and vomiting, diarrhea, low back pain, and fever in the setting of pylephlebitis (septic PVT).2. Chronic PVT may present with after effects of portal hypertension, most often esophageal, and gastric variceal bleeding in the acute hospital setting, even though hyper-splenism and ascites are also seen.Causes:A. Localized:1. Cirrhosis;2. Malignancy – such as hepatocellular carcinoma, gastric and pancreatic adenocarcinoma;3. Abdominal infection;4. Abdominal inflammatory disorders - pancreatitis, cholecystitis, inflammatory bowel disease,5. Injury to portal vein due to surgery or trauma.B. Systemic:1. Hyper-coagulable states, such as anti-phospholipid antibody syndrome;2. Prothrombin G20210A gene mutation,3. Hyper-homocysteinemia,4. Myeloproliferative disease, such as JAK2V617f mutation, and protein C or S deficiencyThese possible causes of PVT can be further classified into three large groups, which is important to know for treatment:1. Cirrhotic-related PVT in the situation of underlying liver disease or cirrhosis;2. Malignancy-related PVT, i.e., in hepatocellular carcinoma, and gastric and pancreatic adenoma;3. Non-cirrhotic PVT, i.e., a genetic hyper-coagulable disorder, anti-phospholipid antibody syndrome, and myelo-proliferative disease.Symptoms:In most instances of PVT, the patient may show few or no symptoms.Some of the most frequent symptoms are:1. Upper abdominal pain2. Abdominal swelling from excess abdominal fluid3. FeverIn cases of cirrhosis-linked PVT, a fluid wave may be identified on examination; this finding is only seldom seen in acute PVT from non-cirrhotic causes.On the other hand, the most frequent features of chronic PVT are splenomegaly and gastrointestinal bleeding.DiagnosisThe symptoms of PVT are distinctive:1. Enlarged spleen2. Variceal bleeding3. Vomiting bloodImaging:1. Doppler ultrasonography2. CT Scans3. MRI of the abdomen4. AngiographyTreatment:Immediate treatmentThe doctor should consider urgent surgical intervention if there is worry about bowel infarction, perforation from diverticulitis, or cholecystitis.Early use of antibiotics is proper in the presence of sepsis or suspicion for pylephlebitis.Some doctors advise anticoagulation (grade 1B level of evidence) for the treatment of symptomatic PVT.If there is no contraindication to anticoagulation, such as active bleeding or a high bleeding risk, anticoagulation should be started in patients with extensive PVTs or symptoms.MedicineFor acute PVT, doctors often give medicine as thrombolytic treatment.Another prescribed medicine the doctor may give is ocetrotide.If the patient forms portal vein thrombosis from an infection doctors may give antibioticsSurgerySurgical methods may be done depending on the severity of PVT injury.As a last resort, the doctor may advise shunt surgery.In severe liver damage, the doctor may need to do a liver transplant.TABLE OF CONTENTIntroductionChapter 1 Portal Vein ThrombosisChapter 2 CausesChapter 3 SymptomsChapter 4 DiagnosisChapter 5 TreatmentChapter 6 PrognosisChapter 7 Portal HypertensionChapter 8 Liver CirrhosisEpilogue Less